Why HGP scientists used sperm cell for Human GNOME mapping

Why HGP scientists used sperm cell for Human GNOME mapping

Before few years back, I came across a Human Gnome project and communicated to one of the scientist and asked him the above question. In response they gave me a good explanation. Following is the gist of the multiple email exchanges.

Human body cells contains identical DNA in each cell. They could even take any cell of body, and also had an option to prefer a cell from female body as well. After analysis they concluded that a sperm cell or female egg is the only best option. From these two, they found that getting an egg from female body needs lots of nursing and is not simple to do it. So finally concluded that they would prefer a sperm cell from male body for complete GNOME mapping. 

Another reason for the selection of sperm cell is that "Sperm cell contains maximum soluble proteins" contrary to other cells of the body. Sperm cell being responsible for new creation has maximum soluble proteins. It is also said that length of DNA mapping is equivalent to Manhattan Telephone directory. 

Before few days I was discussing with one of the scientist in the field of crop genetics. He said that the total DNA strand is composed of chemicals. All these chemicals are responsible for the generation or synthesis of further chemicals which are responsible for the operation or function of respective cell.

During engineering we learned "Energy can neither be created nor destroyed, but it can only be converted from one form to another form". It is also commonly known that one ejaculation takes out around 5 ml of semen. This 5 ml of semen contains millions of sperm cells. These millions of sperm cells contains all those chemicals which were responsible for the syntheses of proteins and other required chemicals.  Greatness of this body is that as soon as the semen is taken out of the body, body again starts working to re-generate it again.

Many times I get confused with the medical advice. After donating blood, doctors say that you need to take a gap of 3 months to donate next time. But I have never seen a doctor recommending a patient to not to waste his semen for next 3-6 months or similar period. So that body will regenerate required proteins or cells. I even agree that body has a capability to generate semen within 2-3 hours of loosing it.... But the question is what is the quality of those sperm cells? 

From the young age of 15 a male starts loosing his sperms. Following table shows the average statistics of amount of semen lost in his life which is equivalent to his weight

Age	Day (5 ml/day)	Amount (ml)
15	360	1800
16-20	360	9000
21-25	360	9000
26-30	360	9000
31-35	360	9000
36-40	360	9000
41-45	360	9000
Total		55800

Energy or chemicals which are required to produce these sperm cells comes from the food we eat. If a male continues to loose semen at this rate, but does not consume proper food, then the sperms will be depleted of good quality. These qualities in the sperm are required during the process of birthing.  A sperm has to swim a longer distance, compete with other sperms, break the shell of egg, enter into the egg and grow within the egg for nine months.

All these soluble proteins are part of human body. If the semen is not lost, then these proteins or chemicals are used in the body for the development. Which helps human body to grow stronger.

I also came across a question that our urine also contains thousands of useful chemicals so body does not become weak after loosing them. Answer to this is that urination is body filtration process. But taking semen out of the body is forceful or the process with specific mind body stimulation. Without stimulation semen does not go out of the body.

Identify your own pattern of semen loss and see how many valuable proteins or chemicals you loose every day or till date. Save those proteins for your retirement so that you will die healthy.

Your friend.

MicroStrategy with Google Map

MicroStrategy configuration for Google Map :

Following are high level steps to configure MicroStrategy with Google Map
1) Receive an API key from google to be used with specific domain name
2) Configure and restart MicroStrategy server
3) Create report with Google Map

1) Create Google API key from following location - http://code.google.com/apis/maps/signup.html.  Please refer below screen shot for reference. Put your domain name and accept the terms and conditions.

2) After submitting the page you get a Key and instructions as shown below.

 These instructions helps you to configure your application for
1) Java Script API
2) MAPS API for Flash
3) HTTP Service


After receiving API, now it is a turn to configure MicroStrategy server to use this API.


Deploy and Configure the Google Connector Plugin in MicroStrategy Environment

Log in to the machine where MicroStrategy server is installed. This configuration is with reference to MicroStrategy 9.2.1m.

Copy C:\Program Files (x86)\MicroStrategy\GISConnectors\ConnectorForGoogleMap_ASP folder to MicroStrategy web installation directory at C:\Program Files (x86)\MicroStrategy\Web ASPx\plugins

Open file C:\Program Files (x86)\MicroStrategy\Web ASPx\plugins\ConnectorForGoogleMap\WEB-INF\xml\config\google\googleConfig.xml and copy the key at

<gc>

    <mk isPremier="true">AIAAAAc3lrvue47EqHzTm1nZE7twIdl1eys7cPEt2IRRfWCqWrxdu-</mk>

    <pjs>

        <pj id="B19DEDCC11D4E0EFC000EB9495D0F44F">

            <at id="54BABC8311D59D57C000B28A4CC5F24F" />

            <at id="54BABD9E11D59D57C000B28A4CC5F24F" />

        </pj>

    </pjs>

</gc>

In the 9.2.1 version of the plugin, you'll notice the isPremier="true" flag.  Setting this flag to false or removing it will disable the plugin, which means you'll get a blank map.  Leaving it true but providing a Standard license key will result in the map loading but then closing, and a message from Google saying that your key isn't authorized and instructions for upgrading.

Also in this file, you'll see 3 more GUIDs under the <pjs> tag.  Inside the <pj> tag, put the Project ID that you'll be using this in.  Create multiple <pj> tag entries to support multiple projects.  In the <at> tags, enter the Attribute GUID for the Latitude and Longitude that you'll be using for the report.  If they are Attribute Forms instead of separate Attributes, simply put the same GUID for both.

Restart your Web Server and you're done with the configuration.

Next Step is to configure Report.

1. Create a report with Latitude and Longitude on it and whatever metrics you want.  
2. Make sure that the Row Merged setting is disabled.
3. Run the report, and under the Tools menu, select "Custom Visualizations".  If you don't have that option, you can enable it in the Project Preferences under Project Defaults -> General.  There's a check box to enable it.
4. Check the box at the top to Enable Visualizations for this report, and scroll to the bottom under AJAX and choose Google Map (9.2) or Map (9.2.1+).  It was renamed between versions.
5. Click Visualization Properties and define how your Latitude and Longitude are created, either by separate Attributes or Attribute Forms.

 Next : Integrating Google Map in RSD 

1) Create dataset in the Report Services Document with the following characteristics:

• Primary dataset (used to plot the markers on the map)
• Attributes or attribute forms that supply latitude and longitude
• At least one metric
• Rows and columns that are not merged
• Secondary dataset (Optional, use to display affinity lines)
• At least two metrics: The value of the first metric is used to determine the thickness of the affinity line, and the value of the second metric is used to determine the color of the affinity line

Note: The primary and secondary data providers must have the exact same attribute forms. Otherwise, the affinity lines will not be displayed

Applying the Map Visualization to a Report Grid in a Document 

Configuring the Map Visualization Properties

 

Note that there is a new icon generated with affinity line in below image. When user clicks on this icon, animations are enabled on the affinity lines. When user click a point on the map that has affinity lines originating from it, animations move out along the lines from the originating point. This feature is available in both DHTML and Flash mode.

 

Displaying Image Markers or Dynamic bubbles

1) Create a report with the following characteristics:

• Attributes or attribute forms that supply latitude and longitude
• At least one metric
• Rows and columns that are not merged

2) Apply custom visualization on the report and Configure Map Properties:

Display Google Map in Image Marker or Dynamic Bubble style

• If users are using image markers and apply color-coded threshold, the markers are replaced by circles that are uniformly sized and color-coded based on the threshold color associated with the value of the metric for that location
• If users are using image markers and apply custom image threshold, the markers are replaced by the custom images

 

• If users are using dynamic bubbles on the map, the value of the metric determines the size of the bubbles.
• If users are using dynamic bubbles and apply color-coded threshold, the bubbles are color-coded based on the threshold color associated with the value of the metric for that location.

Note: User should not use dynamic bubbles and apply custom image threshold because it does not yield a meaningful visualization. The bubbles are simply replaced by uniformly-sized bubbles of default radius and color. This is not a recommended configuration.